Dynamics of Thymus-Colonizing Cells during Human Development
نویسندگان
چکیده
منابع مشابه
Dynamics of thymus-colonizing cells during human development.
Here, we identify fetal bone marrow (BM)-derived CD34hiCD45RAhiCD7+ hematopoietic progenitors as thymus-colonizing cells. This population, virtually absent from the fetal liver (FL), emerges in the BM by development weeks 8-9, where it accumulates throughout the second trimester, to finally decline around birth. Based on phenotypic, molecular, and functional criteria, we demonstrate that CD34hi...
متن کاملDynamics of thymus organogenesis and colonization in early human development
The thymus is the central site of T-cell development and thus is of fundamental importance to the immune system, but little information exists regarding molecular regulation of thymus development in humans. Here we demonstrate, via spatial and temporal expression analyses, that the genetic mechanisms known to regulate mouse thymus organogenesis are conserved in humans. In addition, we provide m...
متن کاملDevelopment of regulatory T cells in the human thymus
...........................................................................................................................................7 TIIVISTELMÄ.......................................................................................................................................9 ABBREVIATIONS .................................................................................................
متن کاملHuman skin cells support thymus-independent T cell development.
Thymic tissue has previously been considered a requirement for the generation of a functional and diverse population of human T cells. We report that fibroblasts and keratinocytes from human skin arrayed on a synthetic 3-dimensional matrix support the development of functional human T cells from hematopoietic precursor cells in the absence of thymic tissue. Newly generated T cells contained T c...
متن کاملAcetylcholinesterase in human thymus cells.
Acetylcholinesterase (AChE) was long thought to be an enzyme found specifically at the sites of nerve synapses and neuromuscular junctions. It has also been found to occur, however, in cells that are not involved with neurotransmission. This study presents the ultrastructural localization of AChE activity in human thymus cells, using the indirect thiocholine method. Cytochemical demonstration o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunity
سال: 2006
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2006.01.008